Direct mechanocatalysis using Resonant Acoustic Mixing (RAM)

We demonstrate the first example of direct mechanocatalysis by Resonant Acoustic Mixing (RAM), an emerging mechanochemical methodology that eliminates the need for bulk solvent and milling media. By using a simple copper coil as a catalyst, RAM enables the effective one-pot, 2-step synthesis of triazoles via a combination of benzyl azide formation and copper-catalyzed alkyne-azide click-coupling (CuAAC), on a wide scope of reagents, providing excellent control over reaction stoichiometry, and enabling a simple synthesis of the anticonvulsant drug Rufinamide.