Citri Reticulatae Pericarpium-Reynoutria Japonica Houtt. Herb Pair Suppress Breast Cancer Liver Metastasis by Targeting ECM1-Mediated Cholesterol Biosynthesis Pathway

Xianghui Han,Jue Wang,Yueqiang Chen,Zhanyang Luo, Qionglian Huang, Yu Zhang, Hanjuan Ning,Sheng Liu,Jianyi Wang

SSRN Electronic Journal（2023）

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摘要

•Citri Reticulatae Pericarpium-Reynoutria japonica Houtt. herb pair could effectively reduce breast cancer liver metastasis.•ECM1 promotes breast cancer liver metastasis via cholesterol biosynthesis pathway.•The mechanism of Citri Reticulatae Pericarpium-Reynoutria japonica Houtt. herb pair is partially mediated by disrupting the ECM1-activated cholesterol biosynthesis process in TNBC cells.

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关键词

cholesterol biosynthesis pathway,pericarpium-reynoutria

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