Peripheral Blood Cytokines Levels in Senegalese Women with Cervical Cancer During Chemotherapy

Cervical cancer is the leading cause of cancer deaths of women in developing world.Several studies demonstrated evidences of inflammatory cytokines implication in cancer progression including in initiation, promotion and invasion by affecting the immune surveillance.Our aim was to measure blood circulating pro-and anti-inflammatory cytokines levels, their profiles according to treatment issue and relation with prognostic factors in cervical cancer during chemotherapy.Blood samples were collected from a cohort of 35 cervical cancer women and 42 women healthy controls (HC) with no history of malignancy.For each CP, three samples were taken at three-week intervals.The first one (S1) was taken before initiation of the chemotherapy protocol.S2 and S3 were samples collected respectively at day 21 and day 42.Cytokines levels were evaluated by ELISA.Mean age of patients was 54.1 year (35 -77 yo).In groups, no relation was observed between age and cytokines levels.Before chemotherapy, high levels of IL-6, IL-4 and IFN-γ were ob-