Rosuvastatin alleviates renal injury in cardiorenal syndrome model rats through anti-inflammatory and antioxidant pathways

Background:Cardiorenal syndrome is increasingly common and has been reported to be associated with inflammation and ox-idative stress,and statins have anti-inflammatory and antioxidant effects.Therefore,we designed this experiment to study the pre-ventive effect of statins on cardiorenal syndrome.The aim of the study is to investigate the effect of early rosuvastatin use on cardiorenal syndrome.Method:Forty-five Wistar rats were randomly divided into 3 groups.A unilateral nephrectomy group(Group 1),a unilateral nephrec-tomy+coronary ligation group(Group 2),and a unilateral nephrectomy+coronary ligation+rosuvastatin group(Group 3).Right kidney removal was performed on all rats during the first week,while Group 3 was given statin intragastric administration at 10 mg/kg/d.One month later,coronary ligation was performed on rats in Groups 2 and 3.Group 3 continued statin treatment.After feeding for 3 months and 2 days,the rats were killed;urine and blood were collected and sent to the laboratory for the determination of the urinary protein/creatinine ratio and blood lipid,creatinine,and urea nitrogen levels,respectively.Serum interleukin 1 β,interleukin 6,malondialdehyde,glu-tathione peroxidase,angiotensin Ⅱ,neutrophil gelatinase-associated lipocalin,cystatin C,and B natriuretic peptide levels were also deter-mined.On the day before euthanasia,all rats were anesthetized and examined by cardiac ultrasound.Hematoxylin-eosin and periodic acid-Schiff staining were performed on heart and kidney sections.Results:The ejection fraction in Group 2 was lower than that in Group 1(P＜0.01).The ejection fraction value in Group 3 was lower than that in Group 1(P＜0.01).Interleukin-1β levels in Group 2 were higher than those in Group 1(P＜0.01).Interleukin-1 β levels in Group 3 were lower than those in Group 2(P＜0.01).The malondialdehyde value in Group 3 was lower than that in Group 2(P＜0.05).Histopa-thology showed that Group 1 had slight renal damage,renal injury was aggravated in Group 2,and renal injury was still present in Group 3,but with alleviated morphology.Conclusion:The interaction of the heart and kidneys in rats is related to inflammation and oxidation.Rosuvastatin can slow down the development of the heart-kidney interaction through anti-inflammatory and antioxidant effects.