Identification of Candidate Neural Biomarkers of Obsessive-Compulsive Symptom Intensity and Response to Deep Brain Stimulation

Despite the success of DBS for treatment of refractory OCD, there are currently no robust neural signatures for OC symptoms or initial mood and energy improvements after DBS. This may be due to limited opportunities available for conducting intracranial electrophysiological recordings in natural environments where fluctuations in symptoms take place. Recently available DBS platforms offered a way over this hurdle, allowing for streaming of intracranial neural activity both at home and in the clinic.