Regulation of Gene Activity Is One of the Mechanisms for Changing Radiosensitivity

— The efficient functioning of cells in an organism is carried out using intracellular signaling pathways, the activation of which leads to a change in the profile of genome expression. Differential activation and repression of genes can cause a change in the cell radiosensitivity. Based on published data and the results that we obtained in the experiment, the effect of radiation on the state of some signaling pathways, as well as microRNA, is studied. The possibility of a change in the cell radiosensitivity during the effect on the signaling pathways triggering the programs of cell death or proliferation is analyzed. The approaches of directed influence on the P53 -dependent system of maintaining the genome stability for increasing post-radiation survival, as well as the significance of this system in the formation of long-term consequences of radiation exposure, are considered.