A New Algorithm Identifying Association of Staphylococcus aureus Strains with Low Expression of Filaggrin in Atopic Dermatitis

Latha Satish,Wan-Chi Chang,Arya Dahal, Elizabeth Johansson, Makenna Eversole,Matthew Schuetz,Brittany Grashel, Daniel Spagna, Seth Jenkins, Veronica Velasquez,Andrew Herr,Jocelyn Biagini, David Haslam,Lisa Martin,Gurjit Khurana Hershey

Journal of Allergy and Clinical Immunology（2023）

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摘要

Skin colonization with Staphylococcus aureus (S. aureus; Sa) contributes to the development of atopic dermatitis (AD). AD is associated with low filaggrin (FLG) expression in the skin due to genetic mutations and inflammation. We hypothesized that in the context of low FLG, colonizing Sa strains may have distinct gene patterns.

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staphylococcus aureus,atopic dermatitis,filaggrin,new algorithm identifying association

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