Gpr88 Deletion Impacts Motivational Control Without Overt Disruptions to Striatal Dopamine

Daisy L. Spark,Michela H. Vermeulen,Rocío A. de la Fuente Gonzalez,Cassandra J. Hatzipantelis,Patricia Rueda,Tara Sepehrizadeh,Michael De Veer,Clotilde Mannoury la Cour,Alex Fornito,Monica Langiu,Gregory D. Stewart,Jess Nithianantharajah,Christopher J. Langmead

Biological Psychiatry Global Open Science（2022）

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摘要

Our results highlight that GPR88 regulates motivational control but that disruption of such behaviors following deletion occurs independently of gross perturbations to striatal dopamine at a gene, protein, or functional level. This work provides further insights into GPR88 as a drug target for motivational disorders.

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关键词

Dopamine,GPR88,Motivation,Orphan G protein–coupled receptor,Striatum,Touchscreen

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