Abstract TP182: Relationship Between Cardiovascular Calcification And Stroke Incidence

Purpose: To assess the relationship between cardiovascular calcifications including coronary artery (CAC), aortic valve (AVC), and aortic root (ARC) and stroke incidence in patients with suspected coronary artery disease (CAD). Methods: In the multicenter prospective cohort study, 1187 patients with suspicious of CAD who underwent coronary computed tomography were registered. Cardiovascular events were recorded with prospective follow-up. Cox proportional hazard model with adjustment for total points of Framingham risk score composed with age, sex, total-cholesterol, high-density lipoprotein cholesterol, diabetes mellitus and smoking were conducted. Hazard ratio (HR) and 95% confidence interval (CI) were calculated. Results: A total of 980 patients (mean age, 65 ± 7 years; female, 45.8%) with assessment of CAC, AVC and ARC Agatston scores were analyzed. During a median follow-up of 4.0 years), 19 patients developed stroke and 67 developed cardiac events. Cox proportional hazard analyses showed CAC or AVC Agatston scores were significantly associated with incidence of stroke (Agatston score [/+100 points], HR 1.09 [95% CI: 1.06-1.13], and HR 1.09 [95%CI: 1.05-1.13], respectively). In contrast, CAC or ARC Agatston scores were associated with incidence of cardiac events (Agatston score [/+100 points], HR 1.07 [95%CI: 1.05-1.10], and HR 1.04 [95%CI: 1.02-1.07], respectively). Conclusion: Although higher CAC Agatston scores were significantly associated with incidence of both stroke and cardiac events, higher AVC and ARC were associated with incidence of stroke and cardiac events, respectively.