Association between Pre-Eclampsia and Spontaneous Prelabour Rupture of Membrane (Prom) in Pregnancy

Background: Pre-eclampsia and other hypertensive disorder in pregnancy are among the top causes of maternal and perinatal death globally. About 10% of all pregnancies have pre labor (premature) rupture of membranes (PROM), of which 7%–8% occur after 37–42 weeks. The objective of the study was to observe if pre-eclampsia is associated with spontaneous PROM. Method: Eighty (80) eligible pregnant women with gestational age ≥20 weeks were included in this study. They were divided into 2 equal case and control groups; 40 pregnant women with Pre-eclampsia and 40 pregnant women with normal blood pressure. The association of the risk of spontaneous PROM was assessed among these groups. Results: In this study 87.5% of the Pre-eclampsia case group and 75% of the normotensive control group were primigravida. There was a significant association between the gestational age of 82.5% of the Pre-eclampsia group and 70% of the normotensive group being full term (p=0.034). In the Pre-eclampsia group, there were 29(72.5%) PROM with a significant association (p=0.010), whereas in the normotensive group, there were 4 (10%) PROM with no significant association. The risk of PROM was found among Pre-eclampsia patients. Conclusion: In this study, we concluded that Pre-eclampsia is associated with the risk of spontaneous PROM.