An Endoplasmic Reticulum-Targeted Ratiometric Fluorescent Probe for Hypochlorite Bioimaging Based on Aggregation-Induced Ratiometric Emission

•An AIRE-active pyrene-based fluorescent probe with endoplasmic reticulum-targeting ability has been developed.•The ratiometric fluorescent probe could monitor ClO− with a short response time (within 20 s) and a lower detection limit (269 nM).•The probe has been successfully applied to the imaging of ClO− in the endoplasmic reticulum of living cells and zebrafish.