Spinal Metastasis from Pediatric Supratentorial Glioblastoma: is It the Price of an Extended Survival? an Interesting Case and Review of Literature
Journal of pediatric neurosciences(2022)
摘要
Abstract Glioblastoma (GBM) is the most common of all the primary brain tumors with a dismal prognosis. Pediatric GBM, despite being rare, is associated with a relatively better survival than the adults. However, an increased survival could subject these children to some rare events like a spinal metastasis. Herein, we report an interesting case of a 9-year-old boy who was operated on under emergent circumstances for a left fronto-temporo-insular GBM at our institute. A maximal safe resection of the tumor was achieved followed by adjuvant chemoradiation. The boy was doing well in the follow-up visits until about a year and a half after the surgery when he presented again with quadriparesis. On a cervical spine imaging, a circumferential, enhancing mass was seen draped around the cervicothoracic spinal cord, consistent with a spinal subarachnoid (leptomeningeal) metastatic deposit. We discussed the prognosis and the relatives preferred a supportive treatment. The child eventually died after 4 weeks. We discuss the literature on the incidence, pattern, and outcome of spinal metastasis from supratentorial GBM in general and the pediatric population in particular.
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关键词
Glioblastoma,leptomeningeal,metastasis,pediatric,survival
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