Enantioselective [3 + 2] cycloadditions of terminal allenoates with β-sulfonyl-α,β-unsaturated ketones
Green Synthesis and Catalysis(2023)
摘要
A highly efficient and mild method for [3 + 2] cycloaddition of β-sulfonyl-α,β-unsaturated ketones with terminal allenoates was well-explored and developed. The reactions were successfully performed by applying multifunctional chiral phosphine P6 which was screened from eight chiral phosphorus reagents to finally result in a variety of enantioenriched sulfone-substituted cyclopentenes with two chiral centers (up to 81% yield with 94% ee). Moreover, 2.5 mol% catalytic equivalents were proved to be feasible when this reaction was performed on a 10 mmol scale.
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关键词
terminal allenoates,cycloadditions
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