A first comprehensive look at the order-disorder nature of RTK KIT native and carcinogenic targets
Global Journal of Cancer Therapy(2022)
摘要
Receptors Tyrosine Kinases (RTKs) act as sensors for extracellular ligands, the binding of which triggers dimerization, activation, and autophosphorylation of specific tyrosine (Y) residues in the Cytoplasmic Domain (CD). This leads to the recruitment and activation of multiple downstream signaling proteins, which regulate various aspects of cellular physiology.
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关键词
rtk kit,carcinogenic targets,order-disorder
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