An Immunogenic Cell Death-Related Classification Predicts Prognosis and Response to Immunotherapy in Hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) is one of the world's malignant tumors with high mortality and a worse prognosis. Immunogenic cell death is caused by tumor cells stimulated by stressors to display or release Danger Associated Molecular Patterns (DAMPs)that attract and activate antigen-presenting cells. It would be advantageous to identify biomarkers associated with Immunogenic cell death(ICD) and stratify patients according to their benefits from ICD immunotherapy. Here, we identified two subtypes ICD-related by consensus clustering. ICD-high Subtype has an excellent clinical outcome, abundant immune cell infiltration, and highly active immune response signaling. In addition, we developed and validated an ICD-related risk model that predicts HCC patients' survival and correlates with the tumor immune microenvironment. In conclusion, we have established a new classification system for HCC based on ICD signatures. This stratification has significant clinical outcomes for estimating prognosis and immunotherapy in HCC patients.