Diagnosis and Treatment of Painful Diabetic Peripheral Neuropathy

This monograph offers clinicians up-to-date, evidence-based information regarding the mechanisms involved in inducing nerve fiber damage and neuropathic pain and the spectrum of risk factors and DPN pheno-types across the life span, as well as a novel discussion of the impact of social determinants of health (SDOH) on DPN development and management. It also provides busy clinicians with a customized, stepwise approach to effectively screen for and diagnose DPN in routine care. Additionally, it summarizes the latest guidance on effective pharmacological and nonpharmacological therapeutic strategies for painful DPN, including the respective roles of nutraceutical products, dietary modification, exercise, and new technologies. Finally, this publication outlines knowledge gaps that need to be targeted to identify modifiable risk factors, develop more sensitive assessments, and produce effective therapies to either prevent the progression of or reverse neuropathic disease. It advocates a personalized care approach to ultimately reduce sequelae and the related health care burden and optimize quality of life for people with diabetes and DPN.