1524P Epidemiology and Demography of Gynecological Sarcoma: Results of the Prospective Intergroup Registry for Gynecological Sarcoma REGSA (NOGGO RU1)

Gynecological sarcomas (GS) are orphan diseases associated with poor prognosis. With the aim to improve our understanding of GS, the German registry for gynecological sarcoma (REGSA) prospectively recorded patients’ data with GS treated in real-life clinical practice at initial diagnosis and relapse. We present demographic and epidemiological data of patients with GS at the time of initial diagnosis. An exploratory analysis among 389 patients (enrolled 2015 - 2021) with different histological subtypes of GS was performed and patients’ data were compared to data of the healthy standard population. 389 patients with GS were descriptively evaluated. Leiomyosarcoma (LMS) was the most common histological subtype (47.3%), followed by low-grade endometrial stromal sarcoma (LG-ESS; 17.7%), high-grade ESS (HG-ESS; 10.4%), adenosarcoma (AS; 9.1%) and undifferentiated uterine sarcoma (UUS; 6.2%). Overall, 9.4% of all GS were classified as “other” rarer subtypes. The mean age of patients was 57.4 years (range: 19-88). There were no statistically significant differences in average age at initial diagnosis nor in BMI among patients with different histological subtypes. In contrast, compared to the standard population, the BMI of patients with GS was significantly higher (27.5 kg/m2 vs 25.1 kg/m2, p<0.001). Most of patients had ECOG performance status 0 (68.3%). REGSA patients were less likely to be smokers compared to the national average of German women (13.4% vs 18.6%). Hypertension was the most common comorbidity as observed in 33.2% of all cases, followed by thyroid diseases (18.6%). The prevalence of hypertension in the German female standard population is approximately 30% and approximately every third person will be affected by thyroid diseases in their lifetime. The BMI of patients with GS was significantly higher compared to that of the standard population, but REGSA data showed no statistically significant differences in terms of demographic variables between different histological subtypes of GS. Further research is needed to specify risk factors of GS in order to promote primary prevention of this fatal disease.