Characterization of Global Research Hotspots and Trends on Ten-eleven Translocation 2: Visualization and Bibliometric Analysis (Preprint)

BACKGROUND Ten-eleven translocation (TET) methylcytosine dioxygenase 2 is an essential DNA demethylase that plays an important role in a variety of biological and pathological processes. However, no bibliometric analysis has methodically explored the knowledge domain of TET2 research. OBJECTIVE The aim of this study is to conduct a visual and scientometric analysis of TET2 research and to explore its current landscape, future direction, and research frontiers. METHODS Publications related to TET2 research were retrieved from the Web of Science Core Collection (WoSCC) from 2009 to 2021. Excel, CiteSpace, and VOSviewer were used to perform the bibliometric visualization analysis. RESULTS A total of 2384 articles were retrieved. The number of publications on TET2 has been steadily increasing from 2009 to 2021. The USA is the largest contributor to the topic, with the largest number of publications. Harvard University and the Institut National de la Santé et de la Recherche Médicale were the leading institutions. Levine RL of Memorial Sloan-Kettering Cancer Center is the most prolific and influential author. High-frequency keywords were “tet2”, “DNA methylation”, “5-hrdroxymethylcytosine”, “5-methylcytosine”, “mutations”, “acute myeloid-leukemia”. The emerging research hotspots, according to keyword bursts, include “inflammation”, “gene expression”, “landscape” and “clonal hematopoiesis”. CONCLUSIONS Research with regards to TET2 is constantly evolving and deepening. We provide an objective and comprehensive analysis of the global status, research hotspots, and potential trends in the field of TET2 research by using a bibliometric approach. These results will assist researchers and clinicians in mastering the knowledge structure and future directions of TET2 research, thus guiding follow-up research.