Solvent controlled synthesis of 2,3-diarylepoxy indenones and α-hydroxy diarylindanones and their evaluation as inhibitors of DNA alkylation repair

Rollania Negi,Tapan Kumar Jena, Jyoti,Nikhil Kumar Tuti,Roy Anindya,Faiz Ahmed Khan

Organic & Biomolecular Chemistry（2022）

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摘要

A serendipitous synthesis of indanones is reported; one of the compounds, 2h, showed the lowest IC50 reported so far against the DNA repair enzyme AlkB.

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