Effects of short-term and perioperative antiviral therapy on prognosis after hepatectomy for hepatitis B virus-related hepatocellular carcinoma

Fan Mu,Zhen Zhao, Kun Xu,Liangshuo Hu,Kun Guo,Jianhua Shi,Liang Yu,Yi Lv,Bo Wang

Research Square (Research Square)（2022）

First Affiliated Hospital of Xi’an Jiaotong University

Cited 0|Views18

Abstract

Abstract Background: Although the benefits of antiviral therapy against hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) have been proven, researchers have not confirmed the difference in outcomes among patients who receive short-term (at least 24 weeks) or perioperative antiviral therapy after liver hepatectomy for HBV-related HCC. Methods: A retrospective study of patients who underwent hepatectomy for HBV-related HCC at the First Affiliated Hospital of Xi'an Jiaotong University from January 2016 to June 2019 was conducted. Considering the history of antiviral therapy, patients were divided into perioperative (control group, n=108) and short-term antiviral therapy groups (n=108). Results: Baseline clinical and laboratory tests and tumor characteristics were compared between the two groups. The Kaplan–Meier analysis showed a significant difference in overall survival (P<0.0001) and disease-free survival (P=0.035) between the two groups. Multivariate analysis demonstrated that short-term antiviral treatment was independently related to enhanced survival outcome in OS (hazard ratio =0.27; 95% confidence interval= 0.08–0.88, P=0.030). Conclusions: In patients with HBV-related HCC, receiving short-term antiviral therapy for at least 24 weeks resulted in enhanced outcomes.

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Key words

perioperative antiviral therapy,hepatocellular carcinoma,hepatectomy,short-term,virus-related

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