Zinc-responsive acral hyperkeratotic dermatosis

Zinc-responsive acral dermatitis is a rare entity characterized by chronic, persistent, well-defined, hyperpigmented, and hyperkeratotic plaques on the acral regions of the body. One needs to differentiate this disease from its close differentials such as necrolytic migratory erythema and pellagra. Herein, we report a case of zinc-responsive acral hyperkeratotic dermatosis in a 35-year-old female previously treated with multiple topical drugs without any significant improvement. The diagnosis of zinc-responsive dermatosis should be kept in mind in the case of treatment-refractory, hyperpigmented plaques on the hands and feet.