Porous scaffolds with enzyme-responsive Kartogenin release for recruiting stem cells and promoting cartilage regeneration

Xi Yu, Feng Lin,Pengqiang Li,Shifeng Yan,Kunxi Zhang,Wenguo Cui,Jingbo Yin

Chemical Engineering Journal（2022）

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摘要

•Capillarity of scaffolds could absorb and retain EPSCs immediately post-surgery.•MMP-responsive release of drug promoted recruitment and chondrogenesis of ESPCs.•In vivo cartilage defects were repaired in situ by the enzyme-responsive scaffolds.

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关键词

ESPCs recruitment,Polyamino acid,Capillarity,Enzyme-responsiveness,Chondrogenic microenvironment

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