Tissue Resident Memory T Cells (TRM) in Primary, Metastatic and Recurrent Head and Neck Squamous Cell Carcinoma (HNSCC) Tissue

Introduction High numbers of tumour infiltrating lymphocytes (TIL) are known to link to better survival in cancer patients. TRM (CD8+CD103+) are a TIL subgroup and are recognised as a key player of anti-cancer immune response. To assess TRM in primary, metastatic, and recurrent HNSCC tissue we developed a tissue microarray (TMA) and used multiplex immunohistochemistry (MxIHC).