Global Burden of Tuberculosis From 1990 to 2019

Abstract BackgroundTuberculosis especially drug resistance tuberculosis is the most pervasive infectious diseases worldwide. Studies examining the scope, variation and influence factor of the worldwide burden of tuberculosis and drug resistance status are lacking.MethodsIn this cross-sectional study, epidemiologic data were gathered using the Global Health Data Exchange query tool, covering persons of all ages with tuberculosis in 204 countries and 21 regions from January 1, 1990, to December 31, 2019; data analysis was completed on December 1, 2022. All participants met the Global Burden of Disease Study inclusion criteria. We analyzed the incidence, mortality and variation trends and influence factor of drug-susceptible and drug-resistant tuberculosis at global, regional and national levels using data from 1990 to 2019.ResultsOutcomes included incidence, deaths, and disability-adjusted life-years (DALYs) by drug-resistance type. Measures were stratified by region, country and socio-demographic index (SDI). The estimated annual percentage changes (EAPCs) and age-standardized rates (ASR) were calculated to evaluate the temporal trends. We also provide the association of age-standardized incidence rates of tuberculosis and the incidence proportion of drug-resistant tuberculosis (DR-TB) with SDI.ConclusionWe found the incidence, deaths and DALYs for tuberculosis appeared to decrease annually, but the increasing incidence and deaths of drug-resistant tuberculosis in all SDI quintiles raises notable points, especially in low- and middle-income countries. This study suggests an increasing global burden of tuberculosis. And the geographic disparities may provide support for tuberculosis health care planning and resource allocation.