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Limited Efficacy of Decreased Tumor-infiltrating Regulatory T Cells after Transforming Growth Factor-beta Blockade in Murine Pancreatic Ductal Adenocarcinoma

Guo-Chao Zhao,Ning Pu,Abulimiti Nuerxiati,Han-Lin Yin,Lei Zhang,Wen-Hui Lou,Wen-Chuan Wu

Cancer screening and prevention/Cancer screening & prevention（2022）

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Abstract
Background and objectivesRegulatory T cells (Tregs) are a vital cell subset that induces immune tolerance in the tumor microenvironment by secreting suppressive cytokines and inhibiting innate immune cells. Transforming growth factor-beta (TGF-β) plays an important role in this process. However, the effect of TGF-β blockade on intratumoral Tregs and its specific biological role remains unclear.
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