Prognostic Factors Analysis for Regenerative Endodontic Procedures: a Retrospective Study of 116 Cases

Abstract Objective to investigate preoperative factors that may influence the root development of regenerative endodontic procedures (REPs). Patients and Methods A total of 116 teeth in 110 patients treated with REPs in the Paediatric Dentistry Department and Endodontics Department from 2013 to 2017 were included in this study. Factors including aetiology, age, preoperative diagnosis and initial root morphology were collected retrospectively, and the associations between these factors and root development after REPs were analysed by Fisher's exact test and multivariate logistic regression model. Results The overall rate of root development after REPs was 89.7%. The dens evaginatus group showed a higher rate (98.8%) in root development than the trauma group (67.6%) (P < 0.01). There was no significant difference among the different age groups (7–13 years old) or among different preoperative diagnoses regarding root development (P > 0.05). And it showed in the trauma group that the teeth with apical foramen sizes larger than 3 mm obviously continued root development than those smaller than 3 mm (P < 0.01). Multivariate logistic regression indicated that aetiology was significantly correlated with root development of REPs (OR: 1.31, 95% CI: 0.007, 0.627, P < 0.05). Conclusions In the limitation of the present study, aetiology was correlated with the root development of REPs and the REPs achieved better outcomes in the cases caused by dens evaginatus than the trauma cases. Clinical Relevance Aetiology would be considered in the case selection of REPs for immature permanent teeth with necrotic pulp.