Drug-disease association prediction via geometric deep learning and negative sample selection

Research Square (Research Square)(2022)

Cited 0|Views2
No score
Abstract
Abstract Background: Traditional drug development takes a good deal of time and effort, computational drug repositioning enables to discover the underlying mechanisms of drugs, thereby reducing the cost of drug discovery and development. However, present methods merely consider structure-based drug-related network for feature extraction of drugs and diseases in the biological network. Results: In this paper, we develop a novel model, namely DRGDL, based on geometric deep learning and negative sample selection to infer potential drug-disease associations (DDAs), which can more comprehensively make use of the biological features of drugs and diseases. Specifically, the lower-order and higher-order representations of drugs and diseases are captured by two different geometric deep learning strategies, and then negative samples are constructed by a negative selection strategy. A machine learning classifier is applied to complete the prediction task of DDAs by integrating two representations of drugs and diseases. Experiment results demonstrate that DRGDL achieves excellent performance under ten-fold cross-validation on the benchmark dataset.
More
Translated text
Key words
geometric deep learning,deep learning,prediction,drug-disease
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined