Metastatic Malignant Gastric Glomus Tumour: Multidisciplinary Diagnosis & Treatment of a Rare Clinical Entity

Abstract Glomus tumours are uncommon neoplasms that are usually benign, solitary and most often found in the skin and soft tissue of distal extremities. Primary gastric glomus tumors are rare, but well described. Fewer than 15 cases of gastric glomus tumour have been reported to have malignant behaviour with distant metastases. Although surgical resection is effective if feasible, recurrence can occur and there is a paucity of evidence on medical treatment options. Here we present the case of a 69-year-old male with a gastric glomus tumour with metastases to abdominal viscera requiring multidisciplinary care for diagnosis, surgical resection, and multiple lines of systemic/radiation therapy guided by available evidence. Genomic analysis revealed a NOTCH2 rearrangement, described in only two prior works and highlighting future possibilities for targeted therapy.