Acoustic radiation force of elastic spherical shell witheccentric droplet in plane wave acoustic field br

Based on the application of acoustic waves in cell manipulation, a model consisting of an elastic sphericalshell and eccentric droplet is established to simulate a eukaryotic cell and analyze the acoustic radiation force(ARF) on the cell. In this work, we derive an exact expression for the ARF on the liquid-filled spherical shell.The influence of eccentric distance, radius of the eccentric droplet and impedance of the medium inside theliquid-filled spherical shell on the ARF are analyzed numerically. The results show that the ARF is verysensitive to the position and size of the eccentric droplet. As the eccentricity of the eccentric droplet increases,the ARF becomes greater. In a low frequency region (ka<3) the resonance peak point increases, and the positionof the curve ventral point shifts to the high frequency region (ka>3) with the increase of the radius of theeccentric droplet. The effect of the position variation on the ARF is more significant than that of the radiuschange, and both of their effects will be superimposed on each other. The ARF, as a function of ka, is mainlyaffected by the variation of the nucleus characteristic impedance. The ARF amplitude around ka = 5 increasesand the position of the ventral point tends to shift rightwards with the enlargement of the nucleus impedance.Therefore, the radiation response at a certain frequency or in a cell size range can be enhanced when the nucleusimpedance increases. The results of this study provide theoretical basis for the cell sorting and targeted therapy