Serum TCA cycle metabolites in Lewy bodies dementia and Alzheimer's disease: Network analysis and cognitive prognosis

Alberto Jaramillo-Jimenez,Lasse M. Giil,Miguel Germán Borda,Diego A. Tovar-Rios,Kåre Andre Kristiansen,Per Bruheim,Dag Aarsland,George E. Barreto,Rolf Kristian Berge

Mitochondrion（2023）

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摘要

•Serum citrate concentrations in mild dementia could be associated with subsequent cognitive decline.•In mild dementia APOE- ε4 carriers, serum isocitrate concentrations could be associated with subsequent cognitive decline.•Downregulation of the first half of the TCA cycle with upregulation in the latter half, might be indirectly reflected in serum metabolites' networks.

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关键词

Citric acid cycle,Cognitive decline,Dementia,Dementia with Lewy bodies,Alzheimer's disease

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