Acute stress response of the HPA-axis in children with Prader-Willi syndrome: new insights and consequences for clinical practice.

Lionne N Grootjen,Gerthe F Kerkhof,Alicia F Juriaans,Demi J Trueba-Timmermans,Anita C S Hokken-Koelega

Frontiers in endocrinology（2023）

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摘要

Early morning ACTH or 11-DOC levels are not appropriate to determine acute stress-related CAI in children with PWS, thus multiple measurements throughout the night are needed for an accurate interpretation. Our data suggest a delayed response of the HPA-axis during acute stress. Using the 11-DOC peak for the test interpretation is less age-dependent than the ACTH peak. Repeated testing of the HPA-axis over time is not required, unless clinically indicated.

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关键词

acute-stress response,central adrenal insufficiency,hypothalamic,pituitary,adrenal axis,children,Prader-Willi syndrome,hydrocortisone

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