Evaluation of in Vitro Bioactivity and Angiogenesis-Promoting Effect for Mesoporous Bioactive Glass Codoped with Copper and Silver

In this study, through combining the antibacterial ability of silver (Ag) and the angiogenesis-promoting prop-erties of copper (Cu), 80SiO2-15CaO-5P2O5-(5-x)Ag-xCuO (x = 0, 1, 2, 3, 4, and 5), Ag/Cu mesoporous bioactive glass (MBG) (AgCu/80S) were prepared using a sol-gel method. X-ray diffraction (XRD) and inductively coupled plasma-mass spectrometry (ICP-MS) were used to analyze the crystal phase, composition, and metal ion release ability of AgCu/80S. In vitro bioactive assay was used to evaluate AgCu/80S ability to form hydroxyapatite (HA) in phosphate-buffered saline (PBS). Human umbilical vein endothelial cell (HUVEC) migration and tube for-mation assays were performed to evaluate the angiogenesis-promoting properties of AgCu/80S. The results of this study indicate that AgCu/80S has good bioactivity, antibacterial ability, and angiogenesis-promoting properties and is a multifunctional material with significant potential in the field of biomedicine.