Cardiovascular Disease Risk Assessment Using Traditional Risk Factors and Polygenic Risk Scores in the Million Veteran Program.

Jason L Vassy,Daniel C Posner,Yuk-Lam Ho,David R Gagnon,Ashley Galloway,Vidisha Tanukonda,Serena C Houghton,Ravi K Madduri,Benjamin H McMahon,Philip S Tsao,Scott M Damrauer, Christopher J O'Donnell,Themistocles L Assimes,Juan P Casas,J Michael Gaziano, Michael J Pencina,Yan V Sun,Kelly Cho,Peter W F Wilson

JAMA cardiology（2023）

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摘要

Study results suggest that PRSs derived predominantly in European samples were statistically significantly associated with ASCVD in the multiancestry midlife and older-age MVP cohort. Overall, modest improvement in discrimination metrics were observed with addition of PRSs to traditional risk factors with greater magnitude in women and younger age groups.

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cardiovascular disease risk assessment,polygenic risk scores,traditional risk factors,risk factors,cardiovascular disease

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