First Opioid Prescribing in Sweden: Drugs, Doses, and Diagnoses in More Than 600 000 Opioid-Naïve and Cancer Free Patients
Journal of substance use(2023)
摘要
BackgroundOpioid dependence has become a public health problem in several countries.MethodsA cohort study was used to assess first-time dispensed opioids, in 2012-2015, by drug type, doses, oral morphine equivalents, and diagnoses, in Sweden. First-time opioid users aged 18-64 years, previously cancer-free and opioid-naive for at least 6.5 years, were studied. Time trends in opioid use in Sweden 2006-2021 were also studied.ResultsDuring the study, 617,568 patients were dispensed opioids for the first time. The crude proportion of first-time opioid users in the population was 2.7% in 2012 and 2.6% in 2015.The combination product of codeine and paracetamol was the most frequent dispensed opioid with 322,818 patients (52.3%), followed by tramadol (120,271, 19.6%) and oxycodone (104,418, 16.9%). From 2012 to 2015, tramadol as first dispensed opioid dropped from 26.5% to 13.7% and oxycodone increased from 10.0% to 24.4%. For the four most commonly dispensed opioids, the median initial dispensal ranged from 250 to 400 oral morphine equivalents.The most common indication was fracture of the lower leg during inpatient care and back pain for specialized outpatient care.ConclusionTrends in dispensed opioids in Sweden show a shift from tramadol to oxycodone, but do not show an increase in total opioid use.
更多查看译文
关键词
Substance abuse,tramadol,oxycodone,codeine,dispensing,opioid,oral morphine equivalents
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要