A masked, placebo-controlled, randomized clinical trial evaluating safety and the effect on cardiac function of low-dose rapamycin in 17 healthy client-owned dogs.

Brian G Barnett,Sonya R Wesselowski,Sonya G Gordon,Ashley B Saunders,Daniel E L Promislow,Stephen M Schwartz, Lucy Chou,Jeremy B Evans,Matt Kaeberlein,Kate E Creevy

Frontiers in veterinary science（2023）

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摘要

While no clinically significant change in cardiac function was observed in dogs treated with low-dose rapamycin, the drug was well-tolerated with no significant adverse events.

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关键词

diastolic function,aging,age-related decline,echocardiography,geroscience

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