Cross-Linking Assisted Infection Reduction: One-year Follow-up of a Randomized Clinical Trial Evaluating Cross-Linking for Fungal Keratitis

Although the evidence for corneal cross-linking (CXL) as a treatment for fungal keratitis is not robust, clinicians have used adjunctive CXL in hopes that there will be some benefit for this challenging disease. Cross-Linking Assisted Infection Reduction was a randomized, outcome-masked clinical trial that found no benefit to CXL in the primary treatment of filamentous fungal keratitis at 3 months. 1 Prajna N.V. Radhakrishnan N. Lalitha P. et al. Cross-linking-assisted infection reduction: a randomized clinical trial evaluating the effect of adjuvant cross-linking on outcomes in fungal keratitis. Ophthalmology. 2020; 127: 159-166 Abstract Full Text Full Text PDF PubMed Scopus (35) Google Scholar We report on the 12-month outcomes of the Cross-Linking Assisted Infection Reduction trial.