Conserved Peptide Upstream Open Reading Frames Act Via Ribosome Stalling to Regulate Translation in Response to Environmental Signals.
crossref(2021)
摘要
The regulation of protein synthesis plays a key role in growth and development in all organisms. Upstream open reading frames (uORFs) are commonly found in eukaryotic mRNA transcripts and typically inhibit translation of downstream ORFs, in part by stalling ribosomes. Conserved peptide uORFs (CPuORFs) are a rare subset of uORFs, some of which conditionally regulate translation. Here we identify three Arabidopsis CPuORFs that specifically regulate translation of any downstream ORF, in response to the agriculturally significant environmental signals, heat shock and water limitation. Mechanistically, we provide evidence that CPuORF translation causes ribosome stalling, in a peptide sequence-dependent manner, attenuating translation of downstream ORFs. We propose a model in which plant CPuORFs are not simply on/off switches for translation, but rather act conditionally, along a continuum, to fine-tune translation dynamically.
更多查看译文
关键词
peptide
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要