Acupuncture for Oculomotor Nerve Palsy: a Systematic Review Protocol

Abstract Background: Oculomotor nerve palsy(ONP) is a common clinical disease in neurology and ophthalmology which results in serious syndrome such as ptosis, diplopia, and limited eye movement. The major medications treating ONP usually make sense and side effects, while acupuncture is known as a safe and effective therapy for ONP. We aim to evaluate the safety and efficacy of acupuncture in the treatment of ONP.Methods: The following database will be required from PubMed, Cochrane Library, Medline, Chinese Biomedical Literature Database, China National Knowledge Infrastructure (CNKI), Wanfang data, Chinese Scientific Journal Database, including studies and published systematic review in the reference list and grey. Three reviewers will search these databases, select data and evaluate the quality of studies separately. The methodological quality will be measured by the Cochrane risk of bias tool. The Review Manager 5.3 will be used to synthesize collected data.Results: The systematic review will evaluate the safety and efficacy based on current evidence of acupuncture for ONP. The primary outcomes are the therapeutic efficiency, the sizes of palpebral fissure and pupil, the range of eye movement and scores of diplopia. Quality of life, and adverse effects will be assessed as secondary outcomes. Conclusion: The study will provide high-quality recently evidence for evaluating the efficacy of acupuncture for patients with ONP. PROSPERO registration number: CRD42020162140.