Precision association of lymphatic disease spread with radiation-associated toxicity in oropharyngeal squamous carcinomas

AbstractPurposeUsing a cohort of 582 head and neck cancer patients with nodal disease, we employed clustering over a novel graph-based geometrical representation of lymph node spread in order to identify groups of similar patients. We show that these groups are significantly correlated with radiation-associated dysphagia (RAD), and predictive of late aspiration and feeding tube toxicity.Materials and methodsAll patients received radiotherapy for oropharyngeal cancer (OPC) and had non-metastatic affected lymph nodes in the head and neck. Affected lymph nodes were segmented from pretreatment contrast-enhanced tomography scans and categorized according to consensus guidelines. Similar patients were clustered into 4 groups according to a graph-based representation of affected lymph nodes. Correlation between dysphagia associated symptoms and patient groups was calculated.ResultsOut of 582 patients, 26% (152) experienced toxicity during a follow up evaluation 6 months after completion of radiotherapy treatment. Patient groups identified by our approach were significantly correlated with dysphagia, feeding tube, and aspiration toxicity (p <.0005). Conclusion: Our work successfully stratified a patient cohort into similar groups using a structural geometry, graph-encoding of affected lymph nodes in OPC patients, that were predictive of late radiation-associated dysphagia. Our results suggest that structural geometry-aware characterization of affected lymph nodes can be used to better predict radiation-associated dysphagia at time of diagnosis, and better inform treatment guidelines.