Serum changes of PYD, C2C and OC among male brucellosis patients at early period

Abstract Objective Musculoskeletal changes are the most common clinic manifestation of brucellosis,and these musculoskeletal changes are irreversible, so, it is very important to prevention musculoskeletal changes at early stage of human brucellosis . Method This was a case-control study. According to diagnostic criteria of human brucellosis in China(WS269-2007),41 male patients were diagnosed as brucellosis patients at early period (within 6 months) and they were not therapied with drug, 44 \ persons were divided into control group with randomly matching. Venous blood samples were collected from all study subjects, and serum PYD ༌C2C and OC were quantitative measured with method of ELISA. Data were analyzed using SPSS 17.0 software. A p value < 0.05 was considered to be statistically significance. Result The median levels of serum PYD, C2C and OC in the patients group were 278.53 ug/l, 82.23 ug/l, and 8.41ug/l, respectively, while the median levels of serum PYD, C2C and OC in the control group were 210.54 ug/l, 72.74 ug/l and 7.43 ug/l, respectively, there were existing significant differences between patients group and control group (Z = 5.686, 3.997, 3.579, all P = 0.000). Conclusion Serum levels of PYD, C2C and OC were increased among male brucellosis patients at early period, which might be the indicator biomarkers for osteoarticular changes of human brucellosis at early stage..