A Feasibility Study of Non-Invasive Continuous Estimation of Brachial Pressure Derived from Arterial and Venous Lines During Dialysis

Intradialytic haemodynamic instability is a significant clinical problem, leading to end-organ ischaemiaand contributing to morbidity and mortality in haemodialysis patients. Non-invasive continuous bloodpressure monitoring is not part of routine practice but may aid detection and prevention of significantfalls in blood pressure during dialysis. Brachial blood pressure is currently recorded intermittently duringhaemodialysis via a sphygmomanometer. Current methods of continuous non-invasive blood pressuremonitoring tend to restrict movement, can be sensitive to external disturbances and patient movement,and can be uncomfortable for the wearer. Additionally, poor patient blood circulation can lead to unreliable measurements. In this feasibility study we performed an initial validation of a novel methodand associated technology to continuously estimate blood pressure using pressure sensors in the extracorporeal dialysis circuit, which does not require any direct contact with the person receiving dialysistreatment.The paper describes the development of the measurement system and subsequent in vivo patient feasibility study with concurrent measurement validation by Finapres Nova experimental physiological measurement device. We identify a mathematical function to describe the relationship between arterial linepressure and brachial artery BP, which is confirmed in a patient study. The methodology presented requires no interfacing to proprietery dialysis machine systems, no sensors to be attached to the patient directly, and is robust to patient movement during treatment and also to the effects of the cyclical pressurewaveforms induced by the hemodialysis peristaltic blood pump. This represents a key enabling factor tothe development of a practical continuous blood pressure monitoring device for dialysis patients. This work has been submitted to the IEEE for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessible.