Time series analysis of tuberculosis registration rates from 2007 to 2019 and prediction: could tuberculosis control milestones be achieved in 2020 and 2025 in Henan Province, China?

Abstract Background: The World Health Organization (WHO) End TB Strategy meant that compared with 2015 baseline, the reduction in pulmonary tuberculosis(PTB) incidence rate should be 20% and 50% in 2020 and 2025, respectively. The incidence number of PTB in China accounted for 9% of the global total in 2018, which ranked the second high in the world. From 2007 to 2019, 854,672active PTB cases were registered and treated in Henan Province, China. We need to assess whether the WHO milestones could be achieved in Henan Province. Methods: The active PTB numbers in Henan Province from 2007 to2019, registered in Chinese Tuberculosis Information Management System (CTIMS) were analyzed to predict the active PTB registration rates in 2020 and 2025, which is conductive to early response measures to ensure the achievement of the WHO milestones. The time series model was created by monthly active PTB registration rates from 2007 to 2016, and the optimal model was verified by data from 2017 to 2019. Monthly and annual active PTB registration rates and 95% confidence interval (CI) from 2020 to 2025 were predicted. Results: High active PTB registration rates in March, April, May and June showed the seasonal variations. The exponential smoothing winter’s multiplication model was selected as the best-fitting model. The predicted values were approximately consistent with the observed ones from 2017 to 2019. The annual active PTB registration rates were predicted as 49.2 (95% CI: 36.0-62.5) and 34.3 (95% CI: 17.7-50.8) per 100 ,000 population in 2020 and 2025 , respectively. Compared with the active PTB registration rate in 2015, the reduction will reach 23.7% (95% CI: 3.1%-44.2%) and 46.9% (95% CI: 21.3%-72.5%) in 2020 and 2025, respectively. Conclusions: The high active PTB registration rates in spring and early summer indicates that high risk of tuberculosis infection in late autumn and winter in Henan Province. Without regard to the confidence interval, the first milestone of WHO End TB Strategy in 2020 will be achieved. However, the second milestone in 2025 will not be easily achieved unless there are early response measures in Henan Province, China. Trial registration: Not applicable