Surface-functionalized Zinc MOFs delivering zinc ion and hydrogen sulfide as tailored anti-hindlimb ischemic nanomedicine

Xiaoyu Wang,Bin Gao,Shihai Xia,Wencheng Zhang,Xumin Chen,Zequn Li,Xiangyan Meng,Yakai Feng

Applied Materials Today（2023）

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摘要

•This work developed an efficacious/facile/cost-effective Zn-MOF-based H2S nanosystem.•Surface-functionalized MOFs were more suitable for anti-hindlimb ischemic therapy.•The nanosystem enabled safe and effective H2S delivery.•Endothelial cells and macrophages were co-regulated by zinc ion and H2S.•The nanosystem achieved more effective ischemic rehabilitation.

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关键词

Zinc ion,Hydrogen sulfide,Therapeutic angiogenesis,Critical limb ischemia,MOFs

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