Development of CO2-responsive supramolecular drug carrier system for potential application in anticancer treatment

Enyew Alemayehu Bayle,Fasih Bintang Ilhami,Sin-Yu Huang,Ting-Hsuan Su,Yeong-Tarng Shieh,Jem-Kun Chen,Chih-Chia Cheng

Applied Materials Today（2023）

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摘要

•Multifunctional CO2-responsive supramolecular complex (I-R6G/U-PEG) was developed.•I-R6G and U-PEG spontaneously co-assemble into nanoparticles in aqueous solution.•Nanoparticles undergo enhance selective uptake by cancer cells in CO2-rich media.•CO2-responsive I-R6G/U-PEG nanoparticles induce massive apoptosis in cancer cells.•This new system holds great potential for safer, more effective chemotherapy.

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关键词

Anticancer treatment,CO2 responsiveness,Hypercapnic tumor microenvironment,Supramolecular drug delivery system,Selective cellular internalization

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