Phosphorus magnesium fiber regulates macrophage polarization through TRPM7 to accelerate wound healing

Xuebo Wei,Zhiyong Liao,Liangliang Yang,Fangfang Wu,Shaodong Chen,Chuxiao Shao, Xin Wang,Keshen Xiao,Jian Xiao,Ke Xu,Da Sun,Hongyu Zhang

Applied Materials Today（2023）

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摘要

•A micro-scale phosphorus magnesium fiber (PMF) was designed by treating pure magnesium rod in etching solution.•PMF promoted macrophage polarization and accelerated wound healing in mouse full-layer skin wound model.•PMF promotes wound repair by activating TRPM7 channel protein through long-term sustained release of metal ions.

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关键词

macrophage polarization,phosphorus,magnesium,wound,trpm7

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