Fibronectin extra domain a limits liver dysfunction and protects mice during acute inflammation

Vivek Krishna Pulakazhi Venu,Annalisa Moregola,Lorenzo Da Dalt,Patrizia Uboldi,Fabrizia Bonacina,Andrés Fernando Muro,Giuseppe Danilo Norata

Atherosclerosis Plus（2023）

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摘要

•FN1 and FN_EDA are highly expressed in the liver of obese human.•FN_EDA+ in plasma increases survival during severe sepsis-related inflammation.•FN_EDA + promote neutrophils adherence and migration.

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limits liver dysfunction,acute inflammation,extra domain

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