Affinity-based electrochemical biosensor with antifouling properties for detection of lysophosphatidic acid, a promising early-stage ovarian cancer biomarker

•An affinity-based electrochemical biosensor for early diagnosis of ovarian cancer.•Using stainless steel electrodes to reduce cost and improve sensitivity.•Using silane-based chemistry to overcome non-specific adsorption.•Gelsolin-actin system as the biorecognition surface for detecting LPA.•Proof-of-concept of a label-free biosensor for fabricating a point-of-care device.