Brain Deficit Patterns in Metabolic Illnesses and Their Overlap With Brain Deficits in Neuropsychiatric Disorders

Metabolic illnesses (MET) are common commodities in mental illnesses, including major depressive disorder (MDD), Bipolar Disorder (BD) and Schizophrenia Spectrum Disorder (SSD). We used a large and representative sample to evaluate the effects of the MET on cortical gray matter thickness, subcortical gray matter volumes and regional white matter integrity. We compared the regional effect sizes of MET on the brain with these reported by the largest meta-analytical studies in mental and neurological illness.