A scientific debate: The sword that cleaves chaos of DNAzyme catalysis research
Biomedical Technology(2023)
摘要
Therapeutic DNAzymes with RNA depleting effect are multifunctional building blocks for constructing biological materials. In a recent work published in Nature Chemistry, Holliger group and Chaput group had a wonderful debate base on previously reported approach for tailoring DNAzymes with high mRNA cleavage activity in mammalian cells. Their perspective pushes the catalytic mechanism investigation of DNAzymes to a new stage with more standardization and clarity.
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关键词
dnazyme catalysis research,cleaves chaos,scientific debate
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