Multivalent calix[4]arene-based mannosylated dendrons as new FimH ligands and inhibitors

Alessandro Palmioli, Luca Moretti,Carlo Alberto Vezzoni,Laura Legnani,Paola Sperandeo,Laura Baldini,Francesco Sansone,Cristina Airoldi,Alessandro Casnati

Bioorganic Chemistry（2023）

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摘要

Calix[4]arenes decorated with mannosylated dendrons prevent type 1 pili-mediated adhesion processes induced by UPEC through FimH inhibition.

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关键词

FimH adhesion,Ligand-receptor interaction studies,FimH ligand screening,Lectin-mediated adhesion inhibitors,Anti-adhesive therapies,Anti-virulence,on-cell STD NMR,Carbohydrate-lectin interactions,Multivalent ligands,Calixarenes

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